Degenerative lesions of the lumbar spine
Conditions
Interventions
C group:General anesthesia + intraoperative pumping of normal saline + postoperative sufentanil analgesia group
S group:General anesthesia + intraoperative pumping of esketamine + postoperative esketamine/sufentanil analgesia group
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, male or female, ASA grade I-III; 2. Patients with severe lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis instability need to be treated with surgery; 3. Planned general anesthesia; 4. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with esketamine or esketamine allergy should be contraindicated after comprehensive evaluation; 2. Patients with poorly controlled or untreated hypertension (SBP more than 180mmHg and DBP more than 100mmHg in the resting state); 3. Patients with elevated intracranial pressure and central nervous system injury or disease (except when ventilated appropriately), and patients with a risk of severe elevated intracranial pressure, such as intracranial aneurysm; 4. Patients with ischemic heart disease, congestive heart failure, unstable angina pectoris or myocardial infarction in the past 6 months; 5. Patients with a history of severe mental disorders or using antipsychotic drugs; 6. Patients with high intraocular pressure (such as glaucoma) and penetrating ocular trauma, as well as ocular surgery patients who should not increase intraocular pressure; 7. Patients with a family history of malignant hyperthermia or patients at high risk of malignant hyperthermia (such as strabismus, scoliosis, etc.); 8. Patients with untreated or undertreated hyperthyroidism; 9. No history of drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative sleep quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Ramasy Sedation Score;Cumulative intraoperative opioid consumption;Use of remedial analgesics within 48h after surgery; | — |
Countries
China
Contacts
Public ContactJin Yanwu
The Second Hospital of Shandong University
Outcome results
None listed