Helicobacter pylori infection
Conditions
Interventions
experimental group:susceptibility-guided triple therapy
control group:empiric amoxicillin and clarithromycin-containing bismuth quadruple therapy
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 65 years, male or female 2. 13C urea breath test was positiveThose with gastrointestinal symptoms or age >35 years who require gastroscopy and are judged by a physician to require eradication of Hp ( eradication is recommended without countervailing factors) 3. No previous helicobacter pylori eradication treatment 4. Signed informed consent
Exclusion criteria
Exclusion criteria: 1.Drugs that may affect the study results, such as PPI, H2 receptor antagonists, bismuth, antibiotics or traditional Chinese medicine(Jinghua WeikangGanhai Weikang) with H. pylori inhibitory effect, were taken within 4 weeks before enrollment 2. PCR test showed negative Hp infection 3.Pregnant or breastfeeding women 4. Patients with malignant tumors of digestive tract 5. Patients with a history of gastric or esophageal surgery 6. Allergies to therapeutic drugs 7. Concomitant with severe cardiovascular and cerebrovascular diseases, liver and kidney diseases, hematopoietic system diseases, and mental illnesses 8. Other situations that the doctor deems unsuitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H. pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The resistance rate of Helicobacter pylori to clarithromycin and levofloxacin;Adverse Events ; | — |
Countries
China
Contacts
Public ContactWang Weihong
Peking University First Hospital
Outcome results
None listed