Insomnia and anxiety
Conditions
Interventions
Healthy control group:none
placebo group:Use of placebo preparations that are identical to probiotic preparations except for the probiotic ingredients
probiotic group:Use of probiotic-containing preparations
Sponsors
Nanchang Reproductive Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Healthy control group: 1 gender is not limited, age = 18 years old , = 30 years old 2 Hamilton Anxiety Scale (score 6) 4 the clinical manifestations of depressed state of mind, and accompanied by at least four of the following: ? often inexplicable nervousness, anxiety; ? like to complain, easy to get agitated, some small things and lose their temper, nagging; ? poor concentration, memory loss, a sense of fatigue, energy; ? accompanied by a series of somatic symptoms, such as sleep disorders, early awakening, insomnia, dreaming, and sleep, poor appetite, weight loss tendency; ?, a series of symptoms, such as sleep disorders, early awakening, insomnia, dreams and sleep, poor appetite, weight loss tendency; ?, a series of symptoms, such as sleep disorders, early awakening, insomnia, dreams and sleep Weight loss tendency, etc.; ? always have a sad expression, unwilling to talk to others; ? less activity, slow reaction; ? have a sense of guilt, self-blame, low self-evaluation. 5 Have not taken probiotics or other medications for one month 6 Signed informed consent
Exclusion criteria
Exclusion criteria: 1: Smoking, alcohol abuse; 2: Received medications such as antidiarrheal, bulking agents, probiotics, antispasmodics, and antibiotics within 30 days prior to enrollment; 3: Severe cardiac, pulmonary, renal, and hepatic dysfunction as well as metabolic diseases, received radiotherapy, chemotherapy, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Inventory;Assens Insomnia Scale;High-throughput sequencing; Untargeted metabolomics; Human Salivary Cortisol (SC) ELISA; | — |
Countries
China
Contacts
Public ContactTingtao Chen ; Weijun Chen
Nanchang University/ Nanchang Reproductive Hospital
Outcome results
None listed