Perioperative oxidative stress in children
Conditions
Interventions
Group L:100% oxygen was inhaled during induction of anaesthesia and 30% oxygen was inhaled immediately after intubation until the end of surgery.
Group M:100% oxygen was inhaled during induction of anaesthesia and 50% oxygen was inhaled immediately after intubation until the end of surgery.
Group H:100% oxygen was inhaled during induction of anaesthesia and 80% oxygen was inhaled immediately after intubation until the end of surgery.
Sponsors
The Children’s Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
1 Months to 12 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anaesthesiologists (ASA) classification I-II; (2) Age 1 month-12 years; (3) Proposed laparoscopic pyeloplasty under general anaesthesia.
Exclusion criteria
Exclusion criteria: (1) Intraoperative need for blood transfusion; (2) Preoperative combined hypertension; (3) Preoperative presence of respiratory tract obstruction that affects normal ventilation, such as chronic tonsillitis, adenoid hypertrophy and obstructive sleep apnoea; (4) Combined endocrine diseases such as hypothyroidism/hyperfunction and hypo/hyperadrenocorticism; (5) Combined metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Malondialdehyde;8-Isoprostane;Hydrogen peroxide;Catalase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Superoxide dismutase (SOD);Partial pressure of oxygen in arterial blood;Lactate;Mean arterial pressure;Heart rate;Oxygenation index;Duration of surgery;S100B protein;Cortisol; | — |
Countries
China
Contacts
Public ContactYaoqin Hu
The Children’s Hospital of Zhejiang University School of Medicine
Outcome results
None listed