colorectal cancer
Conditions
Interventions
Remimazolam group1:Infusion of remimazolam tosylate at a rate of 0.5mg/kg/h, remifentanil at a rate of 0.05-0.2ug/kg/min, and propofol at a rate of 1-10mg/kg/h throughout the surgery.
Remimazolam group2:Infusion of remimazolam tosylate at a rate of 1mg/kg/h, remifentanil at a rate of 0.05-0.2ug/kg/min, and propofol at a rate of 1-10mg/kg/h throughout the surgery.
Remimazolam group3:Infusion of remimazolam tosylate at a rate of 1.5mg/kg/h, remifentanil at a rate of 0.05-0.2ug/kg/min, and propofol at a rate of 1-10mg/kg/h throughout the surgery.
Propofol group:Infusion of remifentanil at a rate of 0.05-0.2ug/kg/min, and propofol at a rate of 1-10mg/kg/h throughout the surgery.
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective general anesthesia for laparoscopic radical resection of colorectal cancer in the elderly, regardless of gender. 2.ASA: Grade II-III; 3.Age: =65 years old; 4.Able to independently complete the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA)
Exclusion criteria
Exclusion criteria: 1.Patients with a long history of alcohol consumption, neurological, muscular, endocrine system, or mental disorder history, or those who have been using neuro-psychoactive drugs such as anti-depressants and anti-anxiety medications for a long time; 2.Patients with severe impairment in cardiovascular, respiratory, liver, and kidney functions; 3.Patients with a body mass index below 18.5 kg/? or above 30 kg/?; 4.Patients who are unable to complete a mental function test successfully before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Montreal Cognitive Assessment;The incidence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure;Diastolic blood pressure;Mean arterial pressure;Heartrate;The dosage of remifentanil used during surgery;The dosage of propofol used during surgery;Anesthesia recovery indicators;The occurrence of adverse events within 48 h postoperatively;VisualAnalogueScale/Score,VAS;Extubation and PACU residence times;The incidence of intraoperative hypotension;Postoperative sleep condition; | — |
Countries
China
Contacts
Public ContactYong Pang
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed