colorectal cancer
Conditions
Interventions
Bupivacaine liposomal group:Bupivacaine liposomal group (group B): performed bilaterally with 40 ml of ED95 bupivacaine liposome in patients under ultrasound guidance prior to anesthesia induction
Ropivacaine group:Ropivacaine group (R group): performed bilaterally with 40ml of 0.4% ropivacaine under ultrasound guidance before anesthesia induction
Sponsors
Tianjin People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) I have a clear understanding and voluntarily participate in the study, and I have signed an informed consent form; (2) Planned to undergo elective laparoscopic colorectal cancer resection surgery; (3) ASA level I to III; (4) Clear consciousness, no cognitive impairment or other mental illnesses; (5) Stable condition, able to cooperate in completing research.
Exclusion criteria
Exclusion criteria: 1)BMI 30 kg/m2; 2)Injection site infection; 3)Have taken a long-acting opioid within 3 days or any opioid within 24 hours before surgery; 4)Existing coagulopathy; 5)Recent history of drug or alcohol abuse; 6)Known allergy to one of the study drugs; 7) Patients with acute and critical illnesses (including acute heart failure, acute stroke, acute myocardial infarction, severe infection, etc.); 8)Psychiatric or cognitive impairment that may interfere with perioperative assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accumulated consumption of opioids at 1, 2, 4, 6, 8, 12, 36, and 48 hours after surgery;VAS score at rest and exercise (deep cough, supine position 90 °, etc.) time points;First time using PCA;Patient satisfaction with pain management;Total use of anesthesia and vasoactive drugs during surgery;Intraoperative hemodynamic conditions;First postoperative analgesia time;Postoperative 8hNRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| First exhaust time;Getting out of bed activities and discharge time;Perioperative adverse reactions (nausea, vomiting, fever, itching, constipation, etc.);Incidence of postoperative hemodynamic instability;Patient satisfaction with postoperative pain control was recorded; | — |
Countries
China
Contacts
Public ContactShuhua Xie
Tianjin People's Hospital, No. 190 Jieyuan Road, Hongqiao District, Tianjin
Outcome results
None listed