Major depressive disorder
Conditions
Interventions
Healthy control group:None
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with depression: 1.Age 18-65 years; 2.No gender limitation; 3.Meeting the diagnostic criteria for depressive episode or recurrent depressive disorder according to DSM-5; 4.HAMD-17 score =18; 5.No MECT or systematic psychological therapy received for at least 8 weeks prior to enrollment; 6.Willing to accept antidepressant treatment; 7.Voluntarily participating and capable of signing informed consent. Inclusion criteria for control group: 1.Age and gender matched with patients; 2.Voluntarily participating and capable of signing informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with depression: 1.History of severe physical illness or organic brain disease; 2.Suffering from other mental illnesses besides depression; 3.Individuals belonging to special populations such as pregnant or lactating women. Exclusion criteria for control group: 1.Various mental illnesses, severe physical illnesses, or positive family history of psychiatric disorders; 2.Individuals belonging to special populations such as pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PBMC immune cell proportion and gene expression level;The decrease in HAMD-17 total score from baseline after 8 weeks of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-17 score reduction rate;HAMA;Columbia-Suicide Severity Rating Scale;Chinese version of Biological Rhythms Interview of Assessment in Neuropsychiatry; | — |
Countries
China
Contacts
Public ContactShen He
Shanghai Mental Health Center
Outcome results
None listed