proliferative vitreoretinopathy
Conditions
Interventions
Experimental group:For patients requiring vitrectomy, a posterior approach vitrectomy was performed, taking the intraoperative discarded vitreous
Control subjects:For volunteers who donated corneas, discarded vitreous from patients who donated corneas was taken as a control group
Sponsors
Affiliated Eye Hospital of NanChang University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Source of surgical samples: Select only discarded vitreous samples removed during surgery that meet ethical standards and regulations, and ensure that the sample collection process is approved and monitored. Consider including those samples from patients of different ages, genders, and ethnicities to obtain more comprehensive information. (2) Sample storage conditions: Select only samples that are stored under appropriate conditions to preserve their biological properties. Ensure that samples are stored frozen or immobilized. (3) Pathologic information: Collect and record detailed pathologic information for each sample, including the patient's history of ocular disease and surgical information. This aids in the interpretation and correlation of subsequent results. (4) Experimental technical standards: Ensure that the use of experimental techniques such as high-resolution imaging, spectral analysis, genetic testing, and protein detection follow industry-recognized best practices and standard operating procedures.
Exclusion criteria
Exclusion criteria: (1) Damaged samples: Exclude discarded vitreous samples that have been significantly damaged during surgery or sampling to avoid affecting the reliability of experimental results. (2) Long-stored samples: Avoid discarded vitreous samples that have been stored for a long time or contaminated to ensure that the experimental results reflect the true state of the sample. (3) Disease interfering factors: Exclude discarded vitreous samples from patients who suffer from serious ocular diseases (e.g., infections or intraocular inflammation) to minimize interference of experimental results by external factors. (4) Incomplete information samples: Avoid selecting discarded vitreous samples without complete pathologic information or surgical history to ensure that experimental results can be fully interpreted. (5) Samples that do not meet technical standards: Exclude samples that have problems with the experimental technique and whose quality does not meet the requirements to ensure the reliability and accuracy of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genetic testing;protein expression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitreous fiber bundle density;Mineral deposits in the vitreous humor; | — |
Countries
China
Contacts
Public ContactXu Qihua
Affiliated eye hospital of NanChang University
Outcome results
None listed