Elderly patients with hip fracture
Conditions
Interventions
Dex group:patients in the dexmedetomidine group received infusion of dexmedetomidine (0.2 µg/kg/h) until end of the surgery, and the formula of postoperative analgesia pump (2mg/kg flurbiprofen ester
Control group:equal amount of normal saline will be given and the formula of postoperative analgesia pump (2mg/kg flurbiprofen ester +1ug/kg sufentanil)
Control group:equal amount of normal saline will be given and the formula of postoperative analgesia pump (2mg/kg flurbiprofen ester +1ug/kg
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: adult patients (65-85 y old), with American Society of Anesthesiologists physical status II or III, who will be scheduled for elective hip fracture operation under intraspinal anesthesia
Exclusion criteria
Exclusion criteria: history of hormone use within week before surgery, signs of acute infection, history of immune system, nervous system and mental illness, tuberculosis, hepatitis and other infectious diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood gas analysis;biochemical indexes;visual analogue scale;mini-mental state examination;mini nutritional assessment short form;heart rate;blood pressure;adverse reactions;complications clavien grading;the 1-year survival rate after surgery;postoperative outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| endothelin-1;brain-derived neurotrophic factor;prostacyclin;ß-amyloid protein;tau protein; | — |
Countries
China
Contacts
Public Contactwenjiecheng
Tianjin Hospital, Tianjin
Outcome results
None listed