hyperalgesia
Conditions
Interventions
Morning Control Group:Normal saline infused at induction, maintained until the end of surgery
Afternoon Control Group:Normal saline infused at induction, maintained until the end of surgery
Morning Dose 1:Esketamine infusion 0.2 mg /kg at induction, 2µg/kg/min maintained until the end of surgery
Afternoon Dose 1:Esketamine infusion 0.2 mg /kg at induction, 2µg/kg/min maintained until the end of surgery
Morning Dose 2:Esketamine infusion 0.4mg /kg at induction, 4µg/kg/min maintained until the end of surgery
Afternoon Dose 2:Esketamine infusion 0.4 mg /kg at induction, 4µg/kg/min maintained until the end of surgery
Sponsors
The Third Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: ASA : II-III 2: Thoracoscopic surgery was planned and the duration of surgery was estimated to be 1 to 3 hours 3: Normal thinking and intelligence development, able to understand and sign informed consent, able to cooperate with the experiment 4: The right hand is dominant 5: patients who voluntarily underwent PCIA
Exclusion criteria
Exclusion criteria: 1: accompanied with serious cardiovascular, liver, kidney and other organ system diseases 2: pregnant or lactating women 3: acute and chronic pain such as chronic headache, low back pain and neuropathic pain 4: recent or long-term use of anti-inflammatory drugs, opioids or related disease treatment drugs 5: heavy smoking or drinking 6: patients with frailty or obesity 7: patients allergic to opioids, esketamine, and non-steroidal drugs 8: untreated or poorly controlled hypertension 9: glaucoma, intracranial hypertension and hyperthyroidism 10: patients with neurological and psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperation 24h AUC of Moving Pain NRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pressure pain threshold;Consumption of analgesics; | — |
Countries
China
Contacts
Public ContactHuiting Liu
The Third Affiliated Hospital of Chongqing Medical University
Outcome results
None listed