chronic obstructive pulmonary disease with fungal infection
Conditions
Interventions
AECOPD/FI group:No intervention
Sponsors
The first affiliated hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Agree and sign an informed consent form, fully understand the research content, process, and potential adverse reactions; (2) Age = 40 years old, regardless of gender; (3) AECOPD patients meet the consensus of Chinese experts in the diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary disease; (4) Patients with Aspergillus infection meet the diagnostic criteria of IDSA 2020 guidelines; (5) Broncho-pulmonary candidiasis meets the diagnostic criteria of the Chinese Expert Consensus on the Diagnosis and Treatment of Adult Candidiasis.
Exclusion criteria
Exclusion criteria: (1) Poor prognosis with an estimated survival time of less than 24 hours; (2) Pregnant and lactating women; (3) Concomitant autoimmune diseases; (4) Use oral corticosteroids or immunosuppressants within 2 weeks prior to admission; (5) Concomitant lack of granulocytes; (6) No use of antifungal drugs within 2 weeks prior to admission; (7) Active pulmonary tuberculosis; (8) Concomitant malignant tumors of the blood system or lungs; (9) Concomitant bronchial asthma; (10) Concomitant severe heart, liver, and kidney dysfunction; (11) Acute exacerbation of COPD after enrollment: (12) Patients who refuse to enter the study and are unable to obtain corresponding samples such as BALF and sputum; (13) Participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abundance of microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAT score; | — |
Countries
China
Contacts
Public ContactZhi Ao
The first affiliated hospital of Chongqing Medical University
Outcome results
None listed