postoperative cognitive disorder
Conditions
Interventions
Aged A group:oxygen concentration about 80% under general anesthesia
Aged B group:oxygen concentration about 60% under general anesthesia
Aged C group:oxygen concentration about 40% under general anesthesia
Adult A group:oxygen concentration about 80% under general anesthesia
Adult B group:oxygen concentration about 60% under general anesthesia
Adult C group:oxygen concentration about 40% under general anesthesia
Sponsors
Harbin Medical University Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1: Laparoscopic elective surgery patients aged = 18 years old 2: ASA II-III 3: Mechanical ventilation under general anesthesia is required 4: Expected anesthesia time more than 2 hours 5: Obtained informed consent 6: Accessibility to audiovisual communication
Exclusion criteria
Exclusion criteria: 1: Neurological disorders such as acute stroke, Alzheimer's disease, history of neurosurgery surgery, Parkinson's disease, etc 2: Long term use of sedatives, antidepressants, alcoholism, drug dependence, or patients with mental illnesses 3: Severe cardiac insufficiency (NYHA grade III or IV) 4: Severe respiratory insufficiency such as severe COPD or oxygenation index<300 5: Immune deficiency, use of immunosuppressants or glucocorticoids, organ transplantation, etc 6: Pregnant patients 7: Received surgery or mechanical ventilation treatment within two weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neutrophil-to-lymphocyte ratio, NLR and platelet-lymphocyte ratio, PLR; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3-minute Diagnostic Interview for CAM;The Mini Mental State Examination (MMSE);Intraoperative vital signs (rSO2, SpO2, HR, MAP, ETCO2, P-Peak, T, BIS) ;PaO2;The FRAIL Scale;Postoperative cardiovascular complications ; ICU transfer rate; | — |
Countries
China
Contacts
Public ContactHan Fei
Harbin Medical University Cancer Hospital
Outcome results
None listed