Dental Implant Surgery
Conditions
Interventions
remimazolam group (Group R):0.05 mg/kg remimazolam was pumped within 1 minute, followed by continuous infusion rate at 0.1-0.3 mg/kg/h.
dexmedetomidine group (Group D):0.5 ug/kg dexmedetomidine was pumped within 10 minutes, followed by continuous infusion rate at 0.2-1.0 ug/kg/h
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: ?Aged 65-80 years old; ?ASA ?~?; ?BMI=30Kg/m2
Exclusion criteria
Exclusion criteria: ? Severe cardiovascular diseases: hypertension grade ?, heart failure (ejection fraction 1.46mg/dl, Child-Pugh grade C, glomerular filtration rate <30ml/ min /1.73m2 or end-stage renal disease); ? Severe central nervous system diseases (craniocerebral trauma, acute stroke, progressive dementia); A history of mental illness or long-term use of sedative or depressive medications; ? Patients who are allergic to benzodiazepines or dexmedetomidine; ? Patients with myasthenia gravis and schizophrenia; ? Unable to complete the relevant assessment due to language, hearing, and visual impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cardiovascular adverse events;Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| onset time of sedation;Intraoperative hemodynamic data (HR, MAP);postoperative pain scores;recovery time of sedation;Patients' and dentists' satisfaction scores; | — |
Countries
China
Contacts
Public ContactQiang Luo
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed