recurrent spontaneous abortion and obstetric antiphospholipid antibody syndrome
Conditions
Interventions
study group:The duration of anticoagulant therapy is determined by the patients antibody titer. Start to use LDA 75mg, oral once a day, before pregnancy LDA duration is not limited. Add LMWH 4000IU on
Antibody titers were measured once in the first trimester, and the titers of aPL tested positive before pregnancy were measured monthly starting from 12 weeks. Antibody turned negative for two consecu
Regular Group:Start to use LDA 75mg, oral once a day, before pregnancy LDA duration is not limited. LMWH 4000IU was added once daily subcutaneous injection from confirmation of pregnancy to LDA+LMWH a
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1: Patients with recurrent miscarriage and antiphospholipid antibody syndrome 2: aged between 20 years old and 40 years old 3: Good compliance, sign informed consent form before the experiment
Exclusion criteria
Exclusion criteria: 1: recurrent miscarriage caused by reasons other than the presence of antiphospholipid antibodies 2: good compliance, sign informed consent form before the experiment 3: a history of thrombosis and a history of fetal arrest in the middle and late stages of pregnancy 4: History of premature birth due to severe eclampsia or preeclampsia or severe placental dysfunction 5: Have a history of allergies to low molecular weight heparin or aspirin enteric coated tablets 6: Previous history of gastrointestinal ulcers or gastric bleeding disease 7: Individuals with a history of malignant tumors 8: Patients with mental illness 9: Epilepsy and other neurological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| abortion;Delayed intrauterine development of the fetus;premature delivery;Hypertensive disorder complicating pregnancy;birth defect ;postpartum hemorrhage;Dose and cost of using LMWH during pregnancy; | — |
Countries
China
Contacts
Public ContactHaiyan Wang
Peking University Third Hospital
Outcome results
None listed