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The protective effect of Omega-3 PUFA on aGVHD after allo-HSCT

Crosstalk between gut microbiota and bile acid mediates the protective effect of Omega-3 PUFA on aGVHD after allo-HSCT through maintaining gut barrier function via VDR signaling

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083049
Enrollment
Unknown
Registered
2024-04-15
Start date
2024-05-01
Completion date
Unknown
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hematologic malignancy

Interventions

Enteral Intervention Group:n-3 PUFA + conventional nutrition
Enteral Placebo:conventional nutrition
Parenteral Intervention group:All-in-one + Fish oil lipid emulsion
Parenteral Placebo:All-in-one

Sponsors

The General Hospital of Western Theater Command
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Patients diagnosed with hematologic neoplasms; (2) Plan to receive HSCT treatment; (3) Suitable for the measurement of body composition by bioelectrical impedance analysis; (4) Agree to participate in clinical studies and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) suffering from serious cardiovascular and cerebrovascular diseases, liver and kidney diseases, gastrointestinal diseases, endocrine system diseases, infectious diseases or mental disorders; (2) Allergic to intervention capsules or poor compliance; (3) Unable to continue to complete the intervention study or affect the results of the study due to other reasons.

Design outcomes

Primary

MeasureTime frame
Inflammation parameters;albumin;prealbumin;Retinol binding protein;Bristol score;gut microbiome;Body Composition;

Secondary

MeasureTime frame
Anthropometry parameters;24h dietary recall;

Countries

China

Contacts

Public ContactChao Kang

The General Hospital of Western Theater Command

spiderman123007@163.com+86 28 8657 0983

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026