Effect of dexamethasone combined with ropivacaine epidural analgesia on acute and chronic postoperative pain in patients undergoing video-assisted thoracoscopic pulmonary resection

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400083032

Enrollment

Unknown

Registered

2024-04-15

Start date

2024-04-15

Completion date

Unknown

Last updated

2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Video-assisted thoracoscopic pulmonary resection

Interventions

Experimental group:Intraoperative epidural 0.20% ropivacaine+dexamethasone 10mg (5ml)

Control group:Intraoperative epidural 0.20% ropivacaine+5ml normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Primary thoracoscopic lobectomy was proposed; ?ASA Grade I-III ?BMI is 18-30kg/?; ? Age > 18 years old; ? Patients informed consent

Exclusion criteria

Exclusion criteria: ? Diabetic blood sugar control is poor; ? Previous analgesics dependency history; ?Have received hormone or immunotherapy within the past 6 months; ?Previous history of thoracic surgery; ?Previous history of chemoradiotherapy; ? There are contraindications for epidural anesthesia; ? Patients with mental disorders

Design outcomes

Primary

Measure	Time frame
PCA consumption of epidural sufentanil 0-24h after surgery;	—

Secondary

Measure	Time frame
PCA consumption of epidural sufentanil 24-48h after surgery;Total epidural sufentanil consumption 0-24h and 24-48h after surgery;NRS scores for resting and activity pain at 24 and 48 hours after surgery;Incidence of chronic pain 3 to 6 months after surgery;BPI scale score 3 and 6 months after surgery;The type and dosage of analgesic drugs were added within 48 hours after operation;Recovery time of getting out of bed and intestinal peristalsis within 48h after operation;Postoperative indwelling time of chest tube, length of hospital stay, number of indwelling of drainage tube;	—

Measure

Time frame

PCA consumption of epidural sufentanil 24-48h after surgery;Total epidural sufentanil consumption 0-24h and 24-48h after surgery;NRS scores for resting and activity pain at 24 and 48 hours after surgery;Incidence of chronic pain 3 to 6 months after surgery;BPI scale score 3 and 6 months after surgery;The type and dosage of analgesic drugs were added within 48 hours after operation;Recovery time of getting out of bed and intestinal peristalsis within 48h after operation;Postoperative indwelling time of chest tube, length of hospital stay, number of indwelling of drainage tube;

—

Countries

China

Contacts

Public ContactQichao Wu

Zhongshan Hospital Fudan University

wu.qichao@zs-hospital.sh.cn+86 186 2150 7737

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026