Postoperative delirium and cognitive function
Conditions
Interventions
Permissible hypercapnia group (P group):Group P adopted a low tidal volume protective lung ventilation strategy, with a tidal volume of 6-8ml/kg (suitable tidal volume set according to the patients id
Female: 45.5+0.91 * (height cm-152.4), while adjusting respiratory rate to maintain PaCO2 between 46-55mmHg and pH between 7.2 and 7.35
Routine ventilation group (Group C):Routine ventilation, tidal volume 8-10ml/kg (suitable tidal volume set according to the patients ideal weight: male: 50+0.91 * (height cm-152.4)
Female: 45.5+0.91 * (height cm-152.4), while adjusting respiratory rate to maintain PaCO2 between 35-45mmHg and pH between 7.35-7.45 in Group C.
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? Patients undergoing orthopedic surgery under general anesthesia in our hospital Patients with ASA grades II - III ? are over 65 years old.
Exclusion criteria
Exclusion criteria: ? Patients who have been diagnosed with mental illness or cognitive impairment before surgery. ?Patients with severe obstructive pulmonary disease and potential chronic hypercapnia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium;Postoperative MMSE score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Non targeted omics metabolic analysis of blood;Postoperative 24-hour pain score; Pulmonary complications;Incidence of intracranial hypertension;Nausea and vomiting incidence rate;Pulling time;PACU stay time;Length of hospital stay;Postoperative 24-hour erythrocyte sedimentation rate;Postoperative 24-hour CRP;24PCT;Amount of bleeding; | — |
Countries
China
Contacts
Public ContactCao Jun
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed