Effect of esketamine combined with paravertebral nerve block on postoperative analgesia and inflammation in patients undergoing retrolaparoscopic renal surgery

A randomized controlled study of the effects of esketamine combined with paravertebral nerve block on postoperative analgesia and inflammation in patients undergoing retrolaparoscopic kidney surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400083001

Enrollment

Unknown

Registered

2024-04-12

Start date

2024-04-12

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain and inflammation

Interventions

Test group:Ultrasound-guided intraoperative paravertebral nerve block was performed with 0.375% ropivacaine 20ml in the T11 paravertebral space after induction, and then 0.2mg/kg/h esketamine was cont

Control group:After induction, the ultrasond-guided intraoperative paravertebral nerve block was performed with 0.375% ropivacaine 20ml in the T11 paravertebral space, and then the normal saline was c

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Conforming to the indications for retrolaparoscopic renal surgery (radical nephrectomy + partial nephrectomy); (2) over 18 years of age; ASA Grade I-III; (3) BMI less than 30kg/?; (4) Voluntarily participate and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Severe mental or cognitive impairment (2) There are serious heart, brain, liver diseases (3) Allergic to the investigational drug; Increased intraocular and intracranial pressure (4) Nerve block anesthesia contraindications (abnormal coagulation function, local anesthetic allergy, injection site infection or tumor, etc.) (5) Long-term use of opioids

Design outcomes

Primary

Measure	Time frame
Opioid consumption 48 hours after extubation;	—

Secondary

Measure	Time frame
VAS scores at rest and cough at 6,12,24,48 h after extubation;Leukocyte, C-reactive protein, IL-6 and TNF-a levels before and 12h after surgery; The immune inflammatory index of the system was calculated;First analgesic pump compression time;Hemodynamic indices (HR, MAP, SpO2) at the time of entry (T1) after endotracheal intubation (T2) during skin resection (T3) 10min after skin resection (T4) 1h after skin resection (T5) at the end of surgery (T6);Tracheal extubation time;Ramsay sedation score 10min after extubation;Intraoperative use of sufentanil, propofol and vasoactive agents;	—

Measure

Time frame

VAS scores at rest and cough at 6,12,24,48 h after extubation;Leukocyte, C-reactive protein, IL-6 and TNF-a levels before and 12h after surgery; The immune inflammatory index of the system was calculated;First analgesic pump compression time;Hemodynamic indices (HR, MAP, SpO2) at the time of entry (T1) after endotracheal intubation (T2) during skin resection (T3) 10min after skin resection (T4) 1h after skin resection (T5) at the end of surgery (T6);Tracheal extubation time;Ramsay sedation score 10min after extubation;Intraoperative use of sufentanil, propofol and vasoactive agents;

—

Countries

China

Contacts

Public ContactZejun Niu

Department of Anesthesiology, Affiliated Hospital of Qingdao University

nzj16niu@sina.com+86 186 6180 5522

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026