knee joint disease
Conditions
Interventions
Liposomal bupivacaine group:Mixture of liposomal bupivacaine and ropivacaine local infiltration analgesia
Ropivacaine group: Ropivacaine local infiltration analgesia
Sponsors
The First People's Hospital of Changzhou
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age: 18-75 years old Gender: Both BMI 18-35kg/m2 American Society of Anesthesiologists Class I, II, and III Elective unilateral total knee arthroplasty Written informed consent was obtained
Exclusion criteria
Exclusion criteria: Decline to attend Be pregnant Situations in which the patient is unable to complete the questionnaire online via email or telephone, including cognitive dysfunction, mental disorders Coagulation disorder Local anesthetics should not be used for allergies or any other reason Analgesic drug abuse Insulin-dependent or uncontrolled diabetes is defined as blood glucose >200mg/dl or hemoglobin A1C > 8.0% on the day of surgery Peripheral nerve block or systemic infection Immune impairment (e.g., HIV, long-term glucocorticoid use) Severe pre-existing neuropathy Revision TKA or bilateral TKA Severe hepatic and renal dysfunction (GFR <50 ml/min, Child-Pugh grade C) Patients with active or latent peptic ulcer, diverticulitis, fresh intestinal anastomosis, and nonspecific ulcerative colitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerica Rating Scale 72h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Get out of bed for the first time;Length Of Stay, LOS;Postoperative complications; | — |
Countries
China
Contacts
Public ContactChen Chen
The First People's Hospital of Changzhou
Outcome results
None listed