Lung cancer patient
Conditions
Interventions
Experimental group :Esketamine was given intravenously before incision. Anesthesia was maintained with an esketamine pump
Control group:Routine induction and maintenance
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ?BMI should be 18 ~ 25kg/m^2, ASA grade I ~ ?, and operation time should be longer than 1 hour. ? Age 50-75 years old; ? Patients to be selected for thoracoscopic thoracoscopic surgery with single lung ventilation ? Agree to participate in clinical trial observation and can cooperate with the regular interview
Exclusion criteria
Exclusion criteria: ? According to the ESketamine application guidelines, there are contraindications in the application of esketamine ? Have a history of cerebrovascular disease or craniocerebral surgery ? Carotid artery ultrasonic occlusion > 50% ? The middle cerebral artery vessels of the patient were not detected during the operation ? Recent use of drugs that may affect intracranial pressure, such as glucocorticoids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative neurocognitive impairment score;Middle cerebral artery flow velocity;Mini-Mental State Examination, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| End of surgery. - Time to extubation;Vasoactive drug dosage;PACU residence time;FLACC pain score immediately after extubation;The Riker sedation-agitation score assesses the degree of agitation;Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactMa Jiahai
The Affiliated Yantai Yuhuangding Hospital of Qingdao University
Outcome results
None listed