Postoperative Delirium
Conditions
Interventions
group D:After using the same induction anesthesia regimen, both groups were anesthetized with inhalation of desflurane, and the concentration of desflurane was adjusted to maintain a BIS value between
group P:After using the same induction anesthesia regimen, both groups were infused with propofol to maintain anesthesia and maintain BIS values between 40 and 60
Sponsors
The First Affiliated Hospital of Chongqing Medical University,Chongqing ,China
Eligibility
Sex/Gender
All
Age
65 Years to 120 Years
Inclusion criteria
Inclusion criteria: (1) Age = 65 years old, planning to undergo elective tracheal intubation for general anesthesia surgery; (2) Accepting hip or knee replacement surgery; (3) American Society of Anesthesiologists Classification (ASA Classification): II-III; (4) Sign a written informed consent form; (5) FFP = 3; (6) MMSE 17 points, primary school > 20 points, high school and above > 22 points, university and above > 23 points).
Exclusion criteria
Exclusion criteria: (1) Having a family history of malignant high fever or having experienced malignant high fever; (2) A history of allergies to propofol or desflurane; (3) Plan to postpone tracheal extubation; (4) Those with severe visual and auditory impairments who cannot cooperate; (5) Having a definite diagnosis of neurological diseases or mental disorders (such as Parkinson's disease, dementia, schizophrenia, or depression); (6) Delirium has already existed before surgery (evaluated using the 3D-CAM scale on the day before surgery, see Appendix 3 for details); (7) Long term use of anticholinergic drugs or other drugs that affect the central nervous system before surgery; (8) Participate in other clinical studies within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery time;Tracheal tube extraction time;Time to reach PACU exit standard;The incidence of hypoxemia after extubation;The incidence of nausea and vomiting within 5 days after surgery;Pain level within 24 hours after surgery;Total hospitalization time;Readmission rate within 30 days;Postoperative complications rate; | — |
Countries
China
Contacts
Public ContactJuYing Jin
Departmentof Anesthesiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing ,China
Outcome results
None listed