Constipation and heart failure
Conditions
Interventions
Experimental group:Shouhui Laxative Capsule
Sponsors
ZhuJiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria for chronic heart failure and have a pattern differentiation of qi and yin deficiency syndrome in traditional Chinese medicine; 2. Patients with cardiac function grade I-III; 3. Patients who meet the diagnostic criteria for constipation, have a syndrome differentiation of qi and yin deficiency in traditional Chinese medicine, and constipation occurs after the diagnosis of heart failure; 4. The primary diseases that cause heart failure are coronary heart disease, hypertensive heart disease, pulmonary heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, etc. 5. Age between 60-80 years old, gender is not limited; 6. Those who have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Combined with severe valvular disease, pericardial disease, congenital heart disease, cardiogenic shock, severe myocarditis, malignant arrhythmia, rheumatic heart disease; 2. Patients with pulmonary hypertension, severe chronic obstructive pulmonary disease, acute asthma exacerbation, and severe pulmonary infection; 3. Severe liver disease (ALT= 3 times the upper limit of normal), kidney disease (Cr=3mg/dl or >265µmol/L), hematologic disease, diabetes mellitus with serious complications, severe endocrine disease; 4. Suffering from acute inflammatory bowel disease (ulcerative colitis, Crohn's disease), intestinal obstruction or incomplete intestinal obstruction, perforation of the digestive tract, appendicitis, unexplained abdominal pain, acute abdomen; 5. Patients with malignant tumors; 6. Those with allergies, or allergies to a variety of drugs and foods, or those who are known to be allergic to the ingredients of Shouhui Laxative Capsules; 7. Patients who cannot take oral capsule preparations; 8. Those who have participated in other clinical studies within three months; 9. Those who are suspected or confirmed to have a history of alcohol or drug abuse; 10. Those with a recent history of acute cerebrovascular disease, major surgery and trauma; 11. Those who have taken laxative drugs within 1 week before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of clinical symptoms of constipation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Constipation clinical symptom score;NYHA classification;Six-Minute Walk Test;NT-proBNP;Inflammatory index;Heart failure efficacy score;TCM symptom efficacy score; | — |
Countries
China
Contacts
Public ContactDonghui Liang
ZhuJiang Hospital of Southern Medical University
Outcome results
None listed