Postpartum depression, PPD
Conditions
Interventions
Blank control group ( group C ):None
Esketamine injection group ( group I ):After umbilical cord clamping in cesarean section, a single intravenous injection of esketamine 0.25 mg / kg ( diluted with normal saline to 20 ml, intravenous i
Esketamine pump injection group ( group P ):After umbilical cord clamping in cesarean section, a continuous intravenous infusion of esketamine 0.25 mg / kg ( diluted with normal saline to 20 ml, intra
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Full-term singleton puerpera were scheduled for elective cesarean section under intraspinal anesthesia. 2. ASA?~?. 3. Aged from 20 to 45 years. 4. BMI 18~30 kg/m2. 5. Edinburgh Postpartum Depression Scale score < 10 points before cesarean section.
Exclusion criteria
Exclusion criteria: 1. Contraindications for the use of esketamine. 2. Application of sedative hypnotics and antidepressants within a week. 3. With a history of drug abuse. 4. Allergic to local anesthetics. 5. With severe heart, lung, liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PPD at 6 weeks after operation ( PPD was defined as Edinburgh Postnatal Depression Scale ( EPDS ) score = 10 points at 6 weeks after operation ).; | — |
Secondary
| Measure | Time frame |
|---|---|
| EPDS score at 3 days, 1 week, 4 weeks and 6 weeks after operation.; Pain VAS score and Brief Psychiatric Rating Scale ( BPRS + ) score at 1 day, 2 days and 3 days after operation.; | — |
Countries
China
Contacts
Public ContactRen Li
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed