patient with maintenance hemodialysis
Conditions
Interventions
Treatment Group:Transaural Vagus Nerve Stimulation (taVNS) is performed 30 minutes after the initiation of hemodialysis in MHD patients, with each session lasting for 20 minutes.
Sponsors
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Criteria for Maintenance Hemodialysis (MHD): 1. Age = 18 years; 2. Have been on maintenance hemodialysis for = 3 months, and be in a relatively stable condition; 3. No significant cognitive impairments or severe neurological diseases that may affect the study outcomes; 4. Capable of cooperating with multiple near-infrared brain function imaging collections and cognitive assessments before, during, and one hour after the start of hemodialysis; 5. Capable of cooperating with Vagus Nerve Stimulation (VNS) treatment; 6. Able to understand the purpose of the study, cooperate with the research process, and sign an informed consent form. Criteria for Healthy Subjects: 1. Age = 18 years; 2. No significant cognitive impairments or severe neurological diseases that may affect the study outcomes; 3. Capable of cooperating with near-infrared brain function imaging collections and cognitive assessments; 4. Capable of cooperating with Vagus Nerve Stimulation (VNS) treatment; 5. Able to understand the purpose of the study, cooperate with the research process, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: 1. Significant psychiatric and emotional abnormalities, or a history of neurological or psychiatric diseases; 2. History of epilepsy or convulsions; 3. Severe dementia or language barriers that prevent cooperation in completing scale assessments; 4. Concurrent neurological or musculoskeletal system diseases that affect cognitive function; 5. History of angina, myocardial infarction, or heart surgery within the past year; 6. Progressively worsening medical condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Task-related HbO2 concentration changes (changes in cerebral blood flow).;Resting-state functional connectivity strength.;Heart rate variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| MoCA;CASP;N-Back paradigm reaction time and accuracy; | — |
Countries
China
Contacts
Public ContactZhongli Jiang
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed