Effect of transcranial direct current stimulation on depression status in patients with herpes zoster related pain: a randomized, double-blind, controlled trial

The effect of transcranial direct current stimulation on depression in patients with herpes zoster related pain: a randomized, double-blind, controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400082902

Enrollment

Unknown

Registered

2024-04-10

Start date

2024-04-10

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression status in patients with herpes zoster related pain

Interventions

experimental group:Patients in the experimental group were stimulated with transcranial direct current stimulation using anodal stimulation of the left dorsolateral prefrontal lobe and cathodal stimul

control group:In the control group, the stimulating electrodes were placed on the corresponding site, and the instrument was turned on to give a short "climbing" pseudo-stimulation for 30 s. After tha

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. The diagnosis of ZAP conforms to the consensus of Chinese herpes zoster diagnosis and treatment experts (2022 version); 2. Age >= 18 years old; 3. Hamilton Depression Scale score = 8 points; 4. Have sufficient cognitive ability to independently evaluate the intensity of one's own pain, and complete survey questionnaires on anxiety, depression, sleep quality, etc; 5. There are no serious adverse reactions to conventional antiviral drugs, central analgesics, and tricyclic antidepressants.

Exclusion criteria

Exclusion criteria: 1. Combined intracranial organic lesions or traumatic brain injury; 2. Taking drugs such as naloxone that interfere with the analgesic effect of transcranial direct current stimulation; 3. Acute pain caused by other factors such as gout, trauma, or postoperative pain; 4. Before the onset of neuropathic pain, the patient already had anxiety and depression disorders; 5. Emotional disorders such as anxiety and depression caused by other reasons; 6. Individuals with functional abnormalities in important organs such as the heart, liver, kidneys, and brain; 7. Individuals with cardiac pacemakers, brain stimulation devices, intracranial metal implantation devices, such as arterial clips, skull repairs, etc; 8. Patients undergoing ventriculoperitoneal shunt surgery; 9. Epilepsy patients who have not been well controlled; 10. Unable to independently complete relevant evaluation questionnaires; Or diagnosed with mental illness.

Design outcomes

Primary

Measure	Time frame
Depression score ;	—

Secondary

Measure	Time frame
Anxiety score;Pain;Sleep quality;Adjustment of medication dosage;Patient global impression of change;cognitive function ;	—

Countries

China

Contacts

Public ContactLiping Chen

Affiliated Hospital of Xuzhou Medical University

1132927346@qq.com+86 137 7587 0371

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026