septic shock
Conditions
Interventions
low-dose group:the dosage of norepinephrine exceeded 0.25 µg/(kg·min)
medium-dose group:the dosage of norepinephrine exceeding 0.5 µg/(kg·min)
high-dose group:when the dosage of norepinephrine exceeded 0.75 µg/(kg·min)
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) with sepsis, 2) needing vasoactive drugs to maintain MAP = 65 mmHg after full volume resuscitation (30 mL/kg of crystal solution within 3 h), 3) survival time is greater than 48 hours, and 4) with blood lactate concentration > 2 mmol/L.
Exclusion criteria
Exclusion criteria: 1) age < 18 years, 2) left ventricular dysfunction, 3) unstable coronary syndrome or acute myocardial infarction, 4) noticeable valvular heart disease, 5) mesenteric artery ischemia or vasospasm disease, 6) chronic renal failure, 7) pregnancy, 8) organ transplantation, 9) Raynaud’s phenomenon, 10) related drug allergy,11) previous use of TP.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change of norepinephrine dosage; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse event;Blood pressure;serum lactate level;CRRT time; | — |
Countries
China
Contacts
Public ContactZhenxing Ding
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed