Female infertility
Conditions
Interventions
Mild ovarian stimulation group:Gonadotropins (Gn, including procaine or quinaphrodine) are used at a dose of =125IU/day during the 1st to 5th day of menstruation, and can increase to 150 IU/day accord
Conventional ovarian stimulation group:Each center follows the current antagonist regimen (Gn dose >= 150IU/day), and the current routine luteal support plan (If no special circumstances, recommended
Sponsors
Women's Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Female aged = 1.5 ng/mL, and total number of bilateral antral follicle >= 7 at the initiation of cycle. 3. Planning to undergo cycle with single fresh embryo transfer.
Exclusion criteria
Exclusion criteria: 1. Undergoing PGT. 2. Women with contraindications to assisted reproductive technology or uterine diseases that seriously affect implantation. 3. Ovulation disorders. 4. A history of recurrent miscarriage (loss of 2 or more pregnancies). 5. One or both spouses have chromosomal karyotype abnormalities, excluding chromosomal polymorphisms. 6. Untreated hydrosalpinx with imaging evidence before embryo transfer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| live birth rate of AGA newborns in the first cycle; | — |
Secondary
| Measure | Time frame |
|---|---|
| E2 level in trigger day ;Cost and quantity used of Gn;OHSS rate;Transferable embryo rate;Biochemical pregnancy rate;Clinical pregnancy rate;Miscarriage rate;Live birth rate;The incidence of pregnancy complications;Birth weight;The incidence of macrosomia;The incidence of low birth weight;Adverse neonatal outcomes and incidence of birth defects;Cycle cancellation rate; | — |
Countries
China
Contacts
Public ContactHuang Hefeng, Zhang Dan
School of Medicine, Zhejiang University Women's Hospital, School of Medicine, Zhejiang University
Outcome results
None listed