Delayed neurocognitive recovery(dNCR)
Conditions
Interventions
S-ketamine group:During anesthesia induction, a single intravenous injection of 0.3-0.5mg/kg S-ketamine is administered, followed by continuous intravenous infusion of 0.3mg/kg/h S-ketamine during sur
control group:Inject equal volume of physiological saline during anesthesia induction, and administer continuous intravenous infusion of equal volume of physiological saline during surgery
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old; 2. The American Society of Anesthesiologists (ASA) grades I-IV; 3. Accept heart valve replacement surgery; 4. Voluntarily participate in the experiment and sign an informed consent form
Exclusion criteria
Exclusion criteria: 1. Previous presence of dementia, Parkinson's disease, epilepsy, or mental illness; 2. Preoperative Mini Mental State Scale (MMSE) score<18, indicating neurocognitive impairment; 3. Previous history of cerebral infarction, cerebral hemorrhage, and traumatic brain injury, with a history of being thick and robust as a sequelae; 4. Regular use of sedatives or antidepressants may lead to alcohol or illegal drug abuse disorders. 5. Existence of visual and auditory barriers, or inability to speak Mandarin and communicate; 6. Allergy to S-ketamine 7. Patients with concomitant aortic dissection, pheochromocytoma, intracranial aneurysm, and other diseases 8. Patients with coexisting sinus bradycardia (heart rate<50 beats/min), pathological sinus syndrome, or second degree atrioventricular block or above, or severe cardiac dysfunction that prevents assessment from being completed 9. Patients with severe liver dysfunction (child pugh grade C) and/or renal dysfunction (currently undergoing dialysis treatment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence rate of dNCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| white blood cell,WBC;C-reactive protein,CRP;neutrophil-to-lymphocyte ratio,NLR;Procalcitonin,PCT;IL-6 IL-1ß; | — |
Countries
China
Contacts
Public ContactZejun Niu
Affiliated Hospital of Qingdao University
Outcome results
None listed