Keratoconus patient
Conditions
Interventions
normal control group:None
Interoperatively postoperative group:none
Corneal transplantation postoperative group:none
Sponsors
Third Xiangya Hospital of Central South Universit
Eligibility
Sex/Gender
All
Age
8 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Normal Control Group (Members of the control group in this study are healthy examination patients from the Ophthalmology Outpatient Department of Xiangya Hospital No.3, who voluntarily participate in this study and sign an informed consent form after fully understanding the purpose, procedures, potential risks, and benefits of the research): Aged 8-50 years; No abnormalities in corneal topography and morphological parameters in both eyes; Corrected visual acuity =0.8; Sign an informed consent form, voluntarily accept and cooperate with the treatment. Experimental Group (Meets all conditions ?-?; additionally, KC group meets conditions ? and ?, FFKC group meets conditions ?-?, surgery group and cross-linking group meet condition ?): Aged 8-50 years; History of myopia or astigmatism; Decline in vision; Sign an informed consent form, voluntarily accept and cooperate with the treatment; Slit lamp microscope examination shows at least one positive sign: corneal stroma thinning and conical protrusion forward, Fleischer ring, Vogt's striae, corneal scar; Corneal topography examination reveals abnormal elevation of the anterior and posterior surfaces, among other changes; The opposite eye has a clear case of keratoconus or has undergone cross-linking surgery or corneal transplant surgery; The eye itself shows no symptoms on slit lamp or topography (asymmetric refractive error of paracentral superior and inferior =1.4); Tomography scans (with the best fit sphere BFS as the reference sphere, central anterior and posterior heights are <8 and 13 um, respectively); The eye has undergone corneal transplant surgery or corneal cross-linking surgery and the interval since the surgery is =3 months.
Exclusion criteria
Exclusion criteria: Exclusion Criteria (For both control and experimental groups): Diagnosed with Sjögren's syndrome; History of wearing soft contact lenses within the past 2 weeks, or hard contact lenses within the past 4 weeks; Concurrent conjunctival, corneal, lacrimal, or other eye diseases not related to keratoconus, or history of ocular trauma or surgery due to reasons other than keratoconus (within the past 6 months); Patients with systemic diseases that would affect the observational indicators before and after treatment: such as liver, kidney, blood, and immune diseases, thyroid dysfunction, uncontrolled diabetes, infections, and solid tumors in the days before sample collection; Presence of corneal scars; Pregnant women, women in the gestation period, or lactating women; Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal biomechanical correlation index;Tear inflammatory factors;Corneal topographic map related parameters; | — |
Countries
China
Contacts
Public ContactZhihong Deng
Third Xiangya Hospital of Central South University
Outcome results
None listed