Elderly patients undergoing major abdominal surgery
Conditions
Interventions
Low dose Esketamine group (E1 group):After induction of anesthesia, a load dose of 0.125 mg/kg esketamine was administered, followed by continuous infusion at a rate of 0.125 mg/kg/h until the surgica
High dose Esketamine group (E2 group):After induction of anesthesia, a load dose of 0.25 mg/kg esketamine was administered, followed by continuous infusion at a rate of 0.25 mg/kg/h until the surgical
Blank control group (Group C):Give an equal amount of saline
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: Elderly patients undergoing major abdominal surgery under general anesthesia, age=60 years old, ASAI-III, expect to stay in hospital for at least 3 days after surgery; Patients who signed informed consent forms.
Exclusion criteria
Exclusion criteria: ?BMI > 30kg/m2; ? known allergy to esketamine; ?Known to have hyperthyroidism or pheochromocytoma, grade III hypertension (very high risk), severe arrhythmia, severe cardiovascular and cerebrovascular disease or hemodynamic instability; ? severe hepatic and renal insufficiency; ? Recent use of any tricyclic antidepressants, sedatives, opioids, etc., within the past month; ? Refusal to provide informed consent or failure to cooperate;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality QoR15; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative EEG characteristics of different doses of esketamine combined with propofol;VAS scores ; | — |
Countries
China
Contacts
Public ContactChen Lijian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed