schizophrenia
Conditions
Interventions
Research group:The H7 deep coil was used for deep transcranial magnetic stimulation (DTMs), and the stimulation target was the anterior cingulate cortex (ACC). The stimulation frequency was 20Hz, the
Control group:A pseudo stimulation coil was used. Stimulation was performed 5 times a week for 4 weeks.
Sponsors
Shenzhen Kangning hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Agree to receive neuromodulation therapy and sign an informed consent form; 2. Age range between 18 and 60 years old; Gender unlimited; 3. IQ>69; 4. The course of the disease is = 2 years, and the effect is not good after sufficient treatment with three antipsychotic drugs; 5. The score of the Positive and Negative Symptom Scale PANSS on the Psychiatric Symptom Assessment Scale is greater than or equal to 70 points; During the dTMS clinical intervention study, the type and dosage of drugs are determined by the clinical attending physician and are expected to remain unchanged within the dTMS intervention period. 7. Have not received any modified electroconvulsive therapy within the first month prior to enrollment.
Exclusion criteria
Exclusion criteria: 1. Exclude patients with obvious impulsive or negative tendencies towards dangerous behaviors; 2. Have a history of manic or severe depressive episodes; 3. Have ICD-10 medication or alcohol dependence within the past three months; 4. Exclude a history of severe physical illness, organic brain disease, and mental disorders caused by thyroid or other physical illnesses; Or patients with severe somatic diseases, infectious diseases and immune system diseases; 5. Exclude patients with poor communication comprehension or cognitive impairment who are unable to complete psychological assessment, or those who are unable to complete psychological assessment for other reasons; 6. Contraindications for magnetic resonance imaging: such as pregnant or lactating women or planned pregnancies, patients with pacemakers, patients with aneurysm clips after craniocerebral surgery, patients with ferromagnetic implants, patients with artificial metal valves after cardiac surgery, patients with alloy implants or metal joints, patients with insulin pumps or nerve stimulators in the body, etc. 7. Individuals with claustrophobia who are unable to undergo magnetic resonance imaging scans; 8. There are contraindications for repeated transcranial magnetic therapy, excluding intracranial presence of metallic materials, presence of pacemakers and stents, risk of seizures, and family history of epilepsy. 9.Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical symptoms ;neurocognitive function ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of brain structural and functional changes ; | — |
Countries
China
Contacts
Public ContactZeng Lingyun
Shenzhen Kangning hospital
Outcome results
None listed