rosacea
Conditions
Interventions
IPL-PDT group: Patients were instructed to cleanse their faces with water before the application of fresh 5% ALA cream to the lesion area.After 20 minutes of sheltering from light, excess ALA was remo
minocycline group:Oral minocycline, 50mg twice daily for 8 weeks
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 to 65 years without cognitive impairment, regardless of gender; 2) Diagnosis was based on the 2017 rosacea diagnostic consensus; 3) Patients with a confirmed diagnosis of moderate or severe rosacea (Investigator’s Global Assessment [IGA] scored [3 points); 4) Patients were not suitable for medication for various reasons and voluntarily participated and signed informed consent when informed of alternative options and consented to having their lesions photographed.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of allergies to 5-aminolevulinic acid (ALA), porphyria, danru cream, tetracycline antibiotics or photosensitivity; 2) Recent systemic therapy with typical medications within the last 8 weeks, systemic isotretinoin treatment within the last 6 months; 3) Recent use of phototoxic or photosensitivity drugs within the last 2 months; 4) Patients with other facial skin diseases that may confound the evaluation of efficacy; 5) Patients with serious physical or mental illnesses, and pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the reduction rate of lesion count; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinician's Erythema Assessment scale,CEA;RosaQoL; | — |
Countries
China
Contacts
Public ContactXiuli Wang
Shanghai Skin Disease hospital
Outcome results
None listed