Pulmonary Aspergillosis
Conditions
Interventions
intervention group:In addition to conventional treatment, pharmaceutical care is provided by clinical pharmacists who analyze the reasons for suboptimal blood drug concentration, propose adjustments t
control group:Conventional treatment (doctor uses voriconazole based on clinical experience and adjusts the voriconazole dose based on blood concentration results).
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
13 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (in accordance with the following three criteria) : (1) Patients with confirmed or clinically diagnosed pulmonary aspergillus disease were included in the study. (2) Voriconazole blood concentration test results did not fall within the target concentration range of 1.5 ~ 5.5 µg/mL. (3) Liver biochemistry was assessed as part of the evaluation process.
Exclusion criteria
Exclusion criteria: Exclusion criteria (anyone) : (1)age < 12 years old, (2) individuals undergoing liver transplantation or experiencing liver failure, (3) concomitant administration of medications known to have significant hepatotoxicity such as rifampicin, isoniazid, pyrazinamide, etc. (4) Blood drug concentration samples were collected at an inappropriate time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-level EQ-5D version;cost;Clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| voriconazole concentration;adverse drug reaction; | — |
Countries
China
Contacts
Public ContactGuirong Xiao
West China Hospital, Sichuan University
Outcome results
None listed