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A randomized controlled clinical trial of concentrated growth factor combined with sodium hyaluronate in the treatment of temporomandibular joint osteoarthritis

A randomized controlled clinical trial of concentrated growth factor combined with sodium hyaluronate in the treatment of temporomandibular joint osteoarthritis

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400082712
Enrollment
Unknown
Registered
2024-04-05
Start date
2020-06-20
Completion date
Unknown
Last updated
2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

TMJOA

Interventions

Experimental group:Injection of CGF mixed with SH into the joint cavity
Control group:Add SH into the articular cavity

Sponsors

Stomatological Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: (1) Diagnosis of TMJOA made according to patient history, clinical symptoms, joint function and imaging examination and treatment by the same physician at the Stomatology Hospital of Xi'an Jiaotong University, the injection was performed by the same doctor; (2) Voluntary agreement to participate in the study and provision of a signed informed consent form; (3) Good overall condition, without serious systemic diseases or mental health conditions; (4) In this study, all 60 TMJOA patients had unilateral joint involvement. (5) The patient's age is between 18 and 50 years old.

Exclusion criteria

Exclusion criteria: (1) A history of injections of other drugs or invasive procedures in the joint area within 1 month; (2) Severe bruxism and obvious malocclusion; (3) Rheumatoid disease; (4) A history of severe pulmonary or heart disease; (5) Diabetes or poor blood glucose control; (6) Pregnancy or lactation; (7) Incomplete data; (8) Used blood products or antithrombotic drugs within 2 weeks before blood centrifugation.

Design outcomes

Primary

MeasureTime frame
Repair bone;

Secondary

MeasureTime frame
Clinical symptoms (limited mouth opening, pain, clicking and mandibular movement );

Countries

China

Contacts

Public ContactXinyu Jia; Zhichen Guo

Stomatological Hospital of Xi'an Jiaotong University

1287066003@qq.com+86 182 9919 7280

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026