Chronic respiratory diseases
Conditions
Interventions
intervention group:Participants will be provided with a 30-day supply of oropharyngeal probiotics (30 lozenges) and instructed to take one lozenge per day after brushing their teeth at bedtime. Partic
control group:No oropharyngeal probiotic intervention
Sponsors
School of Medicine, Wuhan University of Science and Technology
Eligibility
Sex/Gender
All
Age
3 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.HCWs (doctors, nurses and lab technicians) aged 22-65 years working full-time in a hospital, and their children aged 3-12 years who attend daycare/school and live with the HCW parent (children are optional) 2.HCW couples or their children have a history of recurrent respiratory infections (more than 3 in the previous year) 3.HCW couple or their child has a history of allergic rhinitis or asthma 4.HCW has signed written informed consent
Exclusion criteria
Exclusion criteria: 1. Immunocompromised or immunodeficient 2. Known allergy to cow's milk proteins 3. History of lower respiratory tract disease 4. History of chronic sinusitis 5. History of rheumatic diseases 6. Infectious diseases, including measles, mumps or rubella 7. Ongoing respiratory infections 8. use of antibiotics within 7 days prior to the study 9. taking other probiotic products within the last 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flora on nasopharyngeal swabs;Viruses on nasopharyngeal swabs; | — |
Countries
China
Contacts
Public ContactWang Qiang
School of Medicine, Wuhan University of Science and Technology
Outcome results
None listed