coronary artery disease
Conditions
Interventions
Group LB:In group LB, Bilateral thoracic paravertebral nerves were blocked with liposomal bupivacaine under ultrasound guidance before anesthesia induction
Group R:In group R, Bilateral thoracic paravertebral nerves were blocked with ropivacaine hydrochloride under ultrasound guidance before anesthesia induction
Sponsors
Jiangsu Province Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1)Age 45-70 years old, gender unlimited;(2) Coronary angiography confirmed multi-vessel lesions with indications for surgery, NYHA cardiac function class II or III, and left ventricular ejection fraction (LVEF) >50%; (3) Postoperative ICU admission; (4) Planned hospitalization for 24 hours after surgery; (5) Willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Refusal to participate; (2) Contraindications to paravertebral nerve block (including thoracic infection, infectious diseases of the skin and soft tissues at the puncture site, or tumors,unclear or abnormal anatomical location of the puncture site, unclear body surface identification, coagulation dysfunction and local anesthetic allergy) (3) Cardiac surgery or second cardiac surgery history, acute cardiac tamponade and myocardial infarction, severe sinus bradycardia, atrioventricular block or sick sinus syndrome; (4) Emergency surgery; (5) Intraoperative conversion to coronary artery bypass grafting under cardiopulmonary bypass; (6) Chronic lung disease in the past, pulse oximetry < 90% without oxygen; (7) Severe hepatic dysfunction; (8) Severe renal insufficiency; (9) Stroke, schizophrenia, depression, Parkinson's disease, epilepsy or dementia; (10) Unable to communicate due to illiteracy, speech impairment, or significant hearing or vision impairment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative myocardial markers and stress indicators;MAP and HR at different time points in the perioperative period;Perioperative opioid use;Postoperative NRS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of postoperative mechanical ventilation;ICU stay time;Hospital stay time;Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactYu Chen
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed