Postoperative pain after laparoscopic radical surgery for colorectal cancer
Conditions
Interventions
Bupivacaine liposome group(experimental group):The patient had an ultrasound-guided bilateral TAP block after anesthesia induction. During the procedure, a lateral approach was utilized, placing the w
Ropivacaine group(control group):Patients underwent ultrasound-guided bilateral TAP block after induction of anesthesia. Operation method: the lateral approach was used, and the line array probe was p
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. 30 years old = age = 70 years old; 2. Patients undergoing elective colorectal laparoscopic surgery under general anesthesia; 3. 18 kg/m2 = BMI = 35 kg/m2; 4. American Society of Anaesthesiologists (ASA) classification I-III; 5. Be able to understand the study process and the use of pain scales; 6. Have no contraindications to study medications; 7. Clearly understand and voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Abnormal liver function: ALT and/or AST >2×ULN or TBIL =1.5×ULN; 2. Severe renal impairment (blood creatinine >176 µmol/L, glomerular filtration rate 1.5 and/or a platelet count < 70,000/ml); 5. Those with combined sensory abnormalities in the innervated dermatomes and peripheral neuropathy; 6. With mental illness or cognitive dysfunction; 7. A history of pulmonary heart disease or heart failure (New York Heart Association class III to IV congestive heart failure); 8. Women who are pregnant or breastfeeding; 9. Those with chronic pain syndromes (defined as reflex sympathetic dystrophy or complex regional pain syndrome); 10. History of drug or alcohol abuse; 11. History of chronic opioid use (more than 3 months or more than 5 mg/day of morphine equivalents for 1 month); 12. Patients undergoing secondary surgery 13. Any other reason why the investigator considers participation in the trial to be inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exercise VAS pain score within 72 hours postoperatively(Calculate the area under the curve); | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of treatments for arrhythmia, hypotension, and hypertension during surgery;Rest VAS pain score at 72 hours postoperatively (calculated area under the curve);Consumption of analgesic drugs during 0-24h, 24-48h and 48-72h postoperatively;Incidence of postoperative nausea and vomiting, dizziness, respiratory depression, and skin itching;Dosage of all drugs used in anaesthesia and total amount of drugs administered;Time of first pain remedy and number of remedies;Time of first postoperative feeding and defecation;Time to first postoperative bed activity;Patient outcome questionnaire (IPOQ scale) scores at 72h postoperatively;Postoperative patient satisfaction;Patient's length of stay; | — |
Countries
China
Contacts
Public ContactShaozhong Yang
Qilu Hospital of Shandong University
Outcome results
None listed