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Effect of autologous serum to the medium on embryonic developmental potential: A prospective multicenter randomized study

Effect of autologous serum to the medium on embryonic developmental potential: A prospective multi-center randomized study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400082656
Enrollment
Unknown
Registered
2024-04-02
Start date
2024-04-22
Completion date
Unknown
Last updated
2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

female infertility

Interventions

Control group:Conventional commercial medium for embryo culture
Autologous serum culture group (ASC group):Autologous serum (5%) is added into conventional commercial medium for embryo culture

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: ? Couples who meet the indication of IVF and undergo IVF-ET treatment; ? Age: the couple ages 20-45 years old; ? More than two times with poor embryos quality (Day3 good-quality embryo rate =20%) during previous IVF treatment.

Exclusion criteria

Exclusion criteria: ? Either of the couples has chromosomal abnormalities; ? Patients with PCOS, endometrioid cyst of ovary, and adenomyosis; ? Obesity (BMI greater than 27) ? Hydrosalpinx ? intrauterine adhesion ? Male partner with sever oligo-astheno-teratozoospermia.

Design outcomes

Primary

MeasureTime frame
good-quality embryo rate (Day3);—

Secondary

MeasureTime frame
Blastocyst formation rate;Good blastocyst rate;Embryo implantation rate;Pregnancy rate;Continuing pregnancy rate;Live birth rate;—

Countries

China

Contacts

Public ContactLiu Suying

Zhongshan Hospital, Fudan University

lsy6592@163.com+86 136 6179 7989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026