Helicobacter pylori infection
Conditions
Interventions
Empirical treatment group:Select any one of the seven quadruple regimens (two antibiotics+PPI+bismuth) recommended by the Fifth National Consensus on the Diagnosis and Treatment of Helicobacter pylori
14 days of treatment
Individualized treatment group:According to the drug sensitivity test, two antibiotics, PPI, and bismuth agents were selected, with conventional doses, twice a day
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. There is no restriction on male or female, age 18-70 years old 2. Patients with Helicobacter pylori infection treated at Peking University Shenzhen Hospital 3. All patients were first eradication therapy 4. Patients with clinically diagnosed Helicobacter pylori infection: positive 13C-urea breath test 5. In line with the indications for eradication of Helicobacter pylori in the Fifth National Consensus Report on the Treatment of Helicobacter pylori Infection in 2017
Exclusion criteria
Exclusion criteria: 1. Those who have a history of taking PPI and antibiotics within one month 2. Those with a history of allergy to "penicillin" or a positive skin test for "penicillin" 3. Those with dysphagia, esophageal cancer or stricture, asthma and poor lung function 4. Pregnant women, women who may be pregnant and breastfeeding 5. Acute upper respiratory tract infection, recent active gastrointestinal bleeding, liver cirrhosis and esophageal varices 6. There are other serious diseases that affect the results of this study, such as severe liver disease, cardiovascular disease, respiratory system disease, etc. 7. The patient cannot complain correctly, such as those suffering from mental illness, severe neurosis and those who cannot cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication or not; | — |
Secondary
| Measure | Time frame |
|---|---|
| Antibiotic resistance of Helicobacter pylori; | — |
Countries
China
Contacts
Public ContactJun-ping Wang
Peking University Shenzhen Hospital
Outcome results
None listed