Intervetion Effect of the Source-monitoring-theory based Auditory Speech Perception Training on Positive Symptoms in Patients with Schizophrenia and the Neural Mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400082650

Enrollment

Unknown

Registered

2024-04-02

Start date

2024-05-01

Completion date

Unknown

Last updated

2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

Patients experimental group:Source-monitoring-theory based auditory speech-perception training

Patients control group:Fundamental sound characteristics based auditory discrimination training

Healthy control group:Source-monitoring-theory based auditory speech-perception training

Eligibility

Sex/Gender

All

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of patients: 1. Patients are evaluated and diagnosed with schizophrenia by a structured clinical interview with DSM-IV-TR Axis I Disorder (SCID-I, Patient Version) by two physicians with attending titles or above; 2. PANSS score > 90 points; 3. Clinical condition allows their participation in cognitive training and magnetic resonance imaging scans; 4. Right-handed, age between 18 and 59 years old; 5. Hearing and corrected vision are normal. Inclusion criteria of healthy controls: 1. No history of mental or neurological disorders with screening of SCID-I (non-patient version); 2. Age between 18 and 60 years old, right-handed; 3. Hearing and corrected vision are normal.

Exclusion criteria

Exclusion criteria: Exclusion criteria of patients: 1. Diseases of the nervous system caused by physical diseases; 2. Past and present history of substance dependence; 3. Organic brain disorders or neurological disorders; 4. Intelligence quotient (IQ) < 70. 5. Received interventions or treatments such as modified electroconvulsive therapy, transcranial magnetic stimulation, or transcranial direct current stimulation within the past 3 months. 6. Take trihexyphenidyl hydrochloride more than 6 mg daily; 7. Individuals with claustrophobia Exclusion criteria of patients: 1. Severe physical illness. 2. Pregnant or lactating women. 3. Individuals with claustrophobia.

Design outcomes

Primary

Measure	Time frame
Psychiatric symptoms;Psychiatric symptoms;Psychiatric symptoms;	—

Secondary

Measure	Time frame
Speech recognition function;Source monitoring function;Cognitive function;Brain structure and function;Self-reference effect;Social function;Social cognition;Social cognition;Quality of life;Intelligence;	—

Countries

China

Contacts

Public ContactChao Wu

Peking University

wuchaowfy@pku.edu.cn+86 135 5293 0435

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026