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Study on the Differentiation Characteristics of Tumor-Specific Memory CD8 T Cells in Drainage Lymph Nodes and Their Response to PD-1 Immunotherapy Mechanism study

Study on the Differentiation Characteristics of Tumor-Specific Memory CD8 T Cells in Drainage Lymph Nodes and Their Response to PD-1 Immunotherapy Mechanism study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400082637
Enrollment
Unknown
Registered
2024-04-02
Start date
2024-04-02
Completion date
Unknown
Last updated
2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cancer, breast cancer, pancreatic cancer

Interventions

Experimental group:CD8T cell transfusion

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: (1)Age = 18 years old; basic normal function of important organs such as heart, lung, liver, and kidney; ECOG score 1 cm); (4)Willing to participate in this clinical study, able to cooperate with researchers, and sign informed consent; (5)No other tumors in the digestive tract, and no occurrence of intestinal obstruction in the past six months; (6)No uncontrollable hypertension, diabetes, heart disease, thrombosis, or active infections.

Exclusion criteria

Exclusion criteria: (1)Patients whose lesions cannot be sampled for ex vivo primary cell culture; (2)no Lack of cancer components after pathological diagnosis; (3)Failure of primary cell isolation and culture; (4)Presence of active infectious diseases, including active pulmonary tuberculosis, known human immunodeficiency virus (HIV) infection; (5)Subjects deemed unsuitable for participation in this clinical study by the investigator

Design outcomes

Primary

MeasureTime frame
Objective Response Rate;Adverse event occurrence rate;

Secondary

MeasureTime frame
ctDNA;

Countries

China

Contacts

Public ContactBeicheng Sun

The First Affiliated Hospital of Anhui Medical University

sunbc0207@163.com+86 137 7641 3940

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026