End stage hip and knee joint disease associated with diabetes
Conditions
Interventions
Group 1:Maintain pre admission oral hypoglycemic medication regimen (use regular insulin as a remedy when blood sugar control is poor)
Group 2:Stop taking oral hypoglycemic drugs and use the basal mealtime insulin regimen. The total daily insulin dose is 0.5U/kg, with basal insulin accounting for half of the total dose. The remaining
Group 3:Stop taking oral hypoglycemic drugs and use a slide insulin regimen, with insulin dosage adjusted according to a predetermined regimen
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who are admitted to the hospital and plan to undergo the first total joint replacement surgery, whose blood sugar level is between 140~400mg/dl, who have a history of diabetes for more than 3 months, who are between 18 and 80 years old, who have received simple diet treatment, any oral hypoglycemic drugs or small dose (daily dose less than 0.4U/kg) insulin treatment before admission
Exclusion criteria
Exclusion criteria: Hyperglycemia without a known history of diabetes, type 2 diabetes requiring large dose (daily dose = 0.4U/kg) of insulin control, inappropriate adjustment of hypoglycemic program after consultation with endocrinologists, cardiac surgery, clinically related liver disease or renal function impairment (serum creatinine 3.0 mg/dL), history of diabetes ketoacidosis, pregnancy, and any mental condition leading to the inability of subjects to make informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose level;Frequency of hypoglycemia ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients using insulin for remedial purposes;Insulin salvage dosage;Hospital stay;Complication;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactZhou Zongke
West China Hospital of Sichuan University
Outcome results
None listed