Angelman syndrome
Conditions
Interventions
AS-intervention group:Taurine supplementation
Control group:Placebo
Sponsors
Hospital of Fudan University at Xiamen
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: ? Age 2-18 years old, male and female; ? Meeting the diagnostic criteria of AS: children with clinically and genetically confirmed AS (including four genotypes) ? Did not take any nutritional supplement containing taurine within 3 months; ? Legal guardians fully understand and sign the informed consent.
Exclusion criteria
Exclusion criteria: ? Abnormal liver and kidney function, chronic lung and heart diseases ? Use of taurine nutritional supplements or drug users in the past 3 months; ? parents or patients refused to participate in the study; ? The investigator judged that the subjects could not comply with the study requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of clinical symptoms in AS;sleep disorder;Feeding problems;Incidence of adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| siezure;Observer-reported assessment of communication;Assessment of development; | — |
Countries
China
Contacts
Public ContactDu Xiaonan
Children's Hospital of Fudan University at Xiamen
Outcome results
None listed