Postoperative stress disorder
Conditions
Interventions
Control Group:Nasal administration of physiological saline
Oxytocin group:Oxytocin nasal spray 40U
Sponsors
the General Hospital of the Western Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) All fractures were caused by traumatic events (such as car accidents, work-related injuries, etc.) and were first treated in our hospital after the injury; (2) Age range from 18 to 65 years old; (3) The American Society of Anesthesiologists grades I to III; (4) Clear consciousness, normal cognitive ability, able to independently or with the help of researchers understand questionnaires and related scales; (5) The patient fully understands and is willing to participate in this study.
Exclusion criteria
Exclusion criteria: (1) Patients with intellectual disabilities and communication barriers; (2) Central nervous system diseases caused by acute trauma, long-term or intermittent coma, and mental disorders; (3) Pathological fractures; (4) Severe organ dysfunction such as heart, brain, and lungs before fracture; (5) Merge malignant tumors;(6) Taboos for nasal administration (such as lesions or injuries in the nasal cavity); (7) Previously allergic to oxytocin; (8) Pregnant women; (9) Patients with hypertension of grade 2 or above; (10) Patients who are unwilling to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SAS-RQ rating; | — |
Secondary
| Measure | Time frame |
|---|---|
| rating;CD-RISC rating;HAD rating;VAS rating;Salivary concentrations of propylene glycol (MDA), cortisol (CORT), and superoxide dismutase (SOD); | — |
Countries
China
Contacts
Public ContactHuang Qingqing
the General Hospital of the Western Theater Command
Outcome results
None listed