sepsis
Conditions
Interventions
Control group:Propofol plus Fentanyl
Intervention Group:Remimazolam Tosilate plus Fentanyl
Sponsors
Taizhou Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Adult patients aged 18 to 75 years old. (2) Diagnosed with sepsis, meeting the following criteria: ? Presence of infection, ? Sequential Organ Failure Assessment (SOFA) score increased by 2 or more points. (3) Initial endotracheal intubation requiring clinical sedation, with an anticipated need for at least 24 hours of mechanical ventilation. (4) Informed consent obtained from the patient prior to the start of the study.
Exclusion criteria
Exclusion criteria: (1) Severe chronic liver disease (Child-Pugh class B or C). (2) Presence of acute myocardial infarction, severe bradycardia (heart rate < 50 beats per minute), second- or third-degree atrioventricular block. (3) Mental disorders (such as schizophrenia, depression), cognitive impairment, epilepsy, history of substance abuse with psychotropic or anesthetic drugs. (4) Diseases requiring deep sedation (Richmond Agitation-Sedation Scale [RASS] score -4 to -5). (5) Patients receiving sedation due to non-tolerant factors of the ventilator (such as epilepsy). (6) Already or expected to cease treatment due to poor prognosis. (7) Loss of hearing or vision, or any other condition that would significantly interfere with the collection of study data. (8) Pregnant or lactating women. (9) Allergy to Remifentanil or propofol. (10) Any other condition deemed by the investigator to be detrimental to the subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the percentage of time within the target sedation range without rescue sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| length of stay in the ICU;Time required to first reach target sedation range;ventilator-free days within 14 days;Incidence of delirium; incidence of cardiovascular adverse events; | — |
Countries
China
Contacts
Public Contactzhang sheng
Taizhou Hospital of Zhejiang Province
Outcome results
None listed