Graft versus-host disease
Conditions
Interventions
Skin GVHD:10× Genomics Visium Spatial Transcriptome Assays
Sponsors
Medical Center of Hematology, the Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) From March 2024 to March 2026, 18-50 years old patients diagnosed with skin GvHD after allogeneic hematopoietic stem cell transplantation in our center were enrolled. (2) Voluntarily participate in this study, and sign the informed consent; (3) Without serious damage of vital organs: ? creatinine 55%; ? Heme >9g/dL, bilirubin < 2.0mg/dl; (4) Blood routine, liver and kidney function, coagulation routine were normal; (5) No other contraindications to skin biopsy; (6) Voluntarily participated in this study and signed informed consent
Exclusion criteria
Exclusion criteria: (1) There is active bleeding caused by drugs or thrombocytopenia; (2) Pregnant or lactating women; (3)Severe heart, kidney or liver dysfunction; (4) Clinically uncontrolled active infection; (5) Inability to understand or follow the study protocol due to clinical symptoms of brain dysfunction or severe mental disease; (6) Patients with severe acute allergic reactions; (7)The investigators considered that other reasons were not appropriate for clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 10× Genomics Visium Spatial Transcriptome-Specific Gene Analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of skin graft-versus-host disease; | — |
Countries
China
Contacts
Public ContactXi Zhang
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed