Lumbar disc herniation
Conditions
Interventions
control group:PRP was not given during or after PETD
PRP1 group:In PRP1 group, 4 ml of PRP + 2 ml of thrombin were injected into the diseased disc and around the nerve root before the end of PETD
PRP2 group:In PRP2 group, 4 ml of PRP + 2 ml of thrombin were injected into the lateral recess of the affected side of the operative spinal segment on the 5th day after PETD
PRP3 group:In PRP3 group, 4 ml of PRP + 2 ml of thrombin were injected into the diseased disc and around the nerve root before the end of PETD,and 4 ml of PRP + 2 ml of thrombin were injected into th
Sponsors
Nanchong psychosomatic hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Age between 30 and 65 years; ? Low back pain with unilateral radiating ache in underbody; L4/5 or L5/S1 interspinous and paravertebral tenderness, ASLR test (+), VAS =5; Lumbar disc herniation was confirmed by MRI or CT ; ? With a poor outcome of conservative treatment; ? Tolerance to anesthesia and surgery; ? With complete data, voluntary participation in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: ? A history of lumbar surgery; ? Lumbar disc herniation with calcification or bone compression; ? Lumbar instability, spondylolisthesis or stenosis; ? The underlying disease cannot tolerate surgery; ?Tuberculosis, tumor, infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oswestry disability index, ODI;visual analogue scale,VAS;CT grading of epidural fibrosis/adhesion CT grading; | — |
Secondary
| Measure | Time frame |
|---|---|
| prostaglandin E2,PGE2;histamine,HA;5-hydroxy-tryptamine,5-HT; | — |
Countries
China
Contacts
Public ContactGuo-qiang Wang
Nanchong psychosomatic hospital
Outcome results
None listed