Postoperative analgesia in patients undergoing orthopedic surgery under general anesthesia
Conditions
Interventions
The Sufentanil group:Sufentanil 2 µg/kg+ Palonosetron 4 µg/kg
Low dose hydromorphone group:Hydromorphone 0.2 mg/kg+ palonosetron 4 µg/kg
High dose hydromorphone group:Hydromorphone 0.3 mg/kg+ Palonosetron 4 µg/kg
Sponsors
Nanjing Jiangning Hospital
Eligibility
Sex/Gender
All
Age
23 Years to 64 Years
Inclusion criteria
Inclusion criteria: ?Patients undergoing elective orthopedic surgery under general anesthesia ? Aged 23-64 years ?ASA I or II ?BMI 22~28 kg/m^2
Exclusion criteria
Exclusion criteria: ? Preoperative heart, liver, lung or renal insufficiency ?Have diabetes, nervous system disease, blood system disease or immune system disease ?Have mental disorders, hearing or speech disorders ?A history of chronic pain ?Have a long history of taking psychotropic drugs or analgesic drugs ?A history of drug or alcohol dependence ?Have a history of depression ?Preoperative anxiety score (SAS) =50 points or depression score (SDS) =53 points ?Have a long history of sleep disorders or preoperative Pittsburgh Sleep Quality Index Scale (PSQI) score >15
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting Visual Analogue Score at 6 h after surgery;Incidence of dizziness and lethargy at 48 h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting Visual Analogue Score at 2,12,24, and 48 h after surgery;Total number of compressions, effective compressions and number of rescue analgesia within 48 h;Postoperative awakening time, extubation time, and hospital stay;Sedation, Self-rating Depression Scale and Pittsburg Sleep Quality Index score at 24 and 48 h after surgery;The occurrence of nausea and vomiting , respiratory depression (SpO 2 <90%) and skin pruritus within 48 h after surgery.; | — |
Countries
China
Contacts
Public ContactWang Wei
Nanjing Jiangning Hospital
Outcome results
None listed