Parkinson's disease
Conditions
Interventions
real group:Real cTBS therapy is performed on the target. Three sets of cTBS treatment were performed daily, during which a 15-minute rest was taken for each completion, followed by a second set of tre
Sham group:Sham cTBS therapy is performed on the target. Three sets of cTBS treatment were performed daily, during which a 15-minute rest was taken for each completion, followed by a second set of tre
Sponsors
the Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients with sporadic Parkinson's disease who met the diagnostic criteria for MDS and experienced at least one frozen gait in the last 1 month; (2) Age 40-75 years old; (3) During the study period, anti-Parkinson's drugs were not adjusted (drug optimization and adjustment were carried out before the study); (4) Hoehn-Yahr stages 2-4; (5) MMSE score ?26 points; (6) There were no injuries to both lower limbs and no MRI contraindications; (7) No stereotactic surgery was performed; (8) No other neurological or mental illness.
Exclusion criteria
Exclusion criteria: (1) secondary Parkinson's disease or Parkinson's combined syndrome; (2) severe heart, liver and renal insufficiency; (3) after deep brain stimulation or other nerve implantation; (4) Have a history of seizures; (5) Mental and psychological abnormalities, unable to cooperate with MRI scanning and TMS intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| UPDRS-III; | — |
Countries
China
Contacts
Public ContactHu Zhengxiang
the Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed