radiation-induce oral mucositis
Conditions
Interventions
I phase group:0.030.060.100.150.21 mol/L lithium mouthwash
Experimental group: Lithium mouthwash
Control group:Placebo mouthwash
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients pathologically diagnosed with non-metastatic head and neck malignant tumors; 2. Aged 18–80 years; 3. Eastern Cooperative Oncology Group performance status of =2; 4. Planning to receive definitive RT or postoperative adjuvant RT; 5. Normal liver, kidney and bone marrow function; 6. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Known to be allergic to lithium or other components of mouthwash or severe allergic constitution; 2. Poor oral hygiene and/or severe periodontal diseases; 3. Any previous RT to the head and neck region, 4. Severe kidney disease, severe cardiovascular disease, myasthenia gravis, Parkinson's disease or epilepsy; 5. Recent use or current use of diuretics or other drugs known to interact with lithium; 6. Deemed unsuitable for the study by the investigators (concomitant with any other severe diseases).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral mucositis ;Taste function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Xerostomia;Quality of life; | — |
Countries
China
Contacts
Public ContactXingchen Peng
West China Hospital , Sichuan University,
Outcome results
None listed